Current Issue : October - December Volume : 2019 Issue Number : 4 Articles : 5 Articles
Cancer remains a major threat to human health worldwide. Cytotoxicity has imposed\nrestrictions on the conventional cytotoxic drug-based chemotherapy. The rapidly-developing\nnanomedicine has shown great promise in revolutionizing chemotherapy with improved efficiency\nand reduced toxicity. Gd@C82(OH)22, a novel endohedral metallofullerenol, was first reported by\nour research group to suppress tumor growth and metastasis efficiently without obvious toxicity.\nGd@C82(OH)22 imprisons tumors by facilitating the formation of surrounding fibrous layers which is\ndifferent from chemotherapeutics that poison tumor cells. In this review, the authors first reported\nthe antineoplastic activity of metallofullerenol Gd@C82(OH)22 followed by further discussions\non its new anti-cancer molecular mechanism-tumor encaging. On this basis, the unparalleled\nadvantages of nanomedicine in the future drug design are discussed. The unique interaction modes\nof Gd@C82(OH)22 with specific targeted biomolecules may shed light on a new avenue for drug\ndesign. Depending on the surface characteristics of target biomolecules, nanomedicine, just like a\ntransformable and dynamic key, can self-assemble into suitable shapes to match several locks for the\nthermodynamic stability, suggesting the target-tailoring ability of nanomedicine....
The objective of the study was to formulate and evaluate once daily, multiparticulate gastroretentive dosage form of baclofen for achieving sustained drug release, reducing side effects and frequency of administration leading to improved patient compliance. Gastroretention was achieved by designing multilayered effervescent pellets using extrusion spheronization technique. The pellet core contained balclofen, an antispastic drug used in the treatment of multiple sclerosis, as a central composite of multilayered particulate system. Sustained release and gastroretention was achieved by means of multiple coating of polymers viz. retardant coat of ethyl cellulose, effervescent layer of sodium bicarbonate and final gas entrapping layer of Eudragit®RLPO. The optimized formulation was characterized for its micromeritic properties, floating lag time, total floating time, in-vitro drug release and in-vivo floating behavior in rabbit by roentgenography. Promising results were obtained as the formulation showed sustained drug release upto 24 h during in-vitro evaluation. Radiological evidences also suggested that the gastroretention period of the floating barium sulfate-loaded pellets was not less than 10 h....
The objective of this study was to evaluate the intradermal delivery of curcumin utilising\npoly(vinylalcohol) (PVA)-based microneedles loaded with curcumin nanosuspension (CU-NS).\nNanoprecipitation was used to formulate the CU-NS which was then incorporated into PVA\nmicroneedles arrays consisting of 11*11 microneedles of conical shape, measuring 900 microm in\nheight and with 300 microm base diameter����.....
Background and Objectives: Lipid-based self-nanoemulsifying drug delivery systems\n(SNEDDS) have resurged the eminence of nanoemulsions by modest adjustments and o_er many\nvaluable opportunities in drug delivery. Chlorpromazine, an antipsychotic agent with poor aqueous\nsolubility--with extensive first-pass metabolism-can be a suitable candidate for the development of\nSNEDDS. The current study was designed to develop triglyceride-based SNEDDS of chlorpromazine\nto achieve improved solubility, stability, and oral bioavailability. Materials and Methods: Fifteen\nSNEDDS formulations of each short, medium, and long chain, triglycerides were synthesized and\ncharacterized to achieve optimized formulation. The optimized formulation was characterized for\nseveral in vitro and in vivo parameters. Results: Particle size, zeta potential, and drug loading of\nthe optimized SNEDDS (LCT14) were found to be������...
The alarming growth of multi-drug resistant bacteria has led to a quest for alternative\nantibacterial therapeutics. One strategy to circumvent the already existing resistance is the use of\nphotodynamic therapy. Antimicrobial photodynamic therapy (aPDT) involves the use of non-toxic\nphotosensitizers in combination with light and in situ oxygen to generate toxic radical species within\nthe microbial environment which circumvents the resistance building mechanism of the bacteria.\nHydrogels are used ubiquitously in the biological and pharmaceutical fields, e.g., for wound dressing\nmaterial or as drug delivery systems. Hydrogels formed by water-insoluble low-molecular weight\ngelators may potentially provide the much-needed benefits for these applications. Bolalipids are\na superior example of such gelators. In the present work, two artificial bolalipids were used, namely\nPC-C32-PC and Me2PE-C32-Me2PE, which self-assemble in water into long and flexible nanofibers\nleading to a gelation of the surrounding solvent. The aim of the study was to create stable hydrogel\nformulations of both bolalipids and to investigate their applicability as a novel material for drug\ndelivery systems. Furthermore, methylene blue--a well-known photosensitizer--incorporated\ninto the hydrogels in order to investigate the aPDT for the treatment of skin and mucosal infections\nusing a custom designed LED device....
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